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These cells are a crucial part of the adaptive immune system, important for recognizing and fighting specific pathogens

Though G6PD is found in the cytoplasm of all mammals cells, its deficiency is more evident in the red blood cells probably because these cells live without nucleus for a long time and because they contain proteases that degrade the mutant enzyme in major degree than other proteases in other tissues 1

Similar to DON, acivicin and azaserine are also glutamine analogs that interrupt nucleotide synthesis by inhibiting amidotransferases [110, 116]

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Neelakantan H, et al